Flavonoids in cancer and apoptosis

M Abotaleb, SM Samuel, E Varghese, S Varghese… - Cancers, 2018 - mdpi.com
Cancer is the second leading cause of death globally. Although, there are many different
approaches to cancer treatment, they are often painful due to adverse side effects and are …

A recent review of citrus flavanone naringenin on metabolic diseases and its potential sources for high yield-production

N Karim, Z Jia, X Zheng, S Cui, W Chen - Trends in Food Science & …, 2018 - Elsevier
Background Metabolic syndromes are the multi-metabolic abnormality characterized by
hyperlipidemia, obesity, hyperglycemia, diabetes, hypertension, cardiovascular disease …

Organometallic gold (III) complexes similar to tetrahydroisoquinoline induce ER-stress-mediated apoptosis and pro-death autophagy in A549 cancer cells

KB Huang, FY Wang, XM Tang, HW Feng… - Journal of medicinal …, 2018 - ACS Publications
Agents inducing both apoptosis and autophagic death can be effective chemotherapeutic
drugs. In our present work, we synthesized two organometallic gold (III) complexes …

Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53

HJ Shin, HK Kwon, JH Lee, X Gui, A Achek, JH Kim… - Scientific reports, 2015 - nature.com
Necrosis, unregulated cell death, is characterized by plasma membrane rupture as well as
nuclear and cellular swelling. However, it has recently been reported that necrosis is a …

Pharmacological properties and therapeutic potential of naringenin: a citrus flavonoid of pharmaceutical promise

N Rani, S Bharti, B Krishnamurthy… - Current …, 2016 - ingentaconnect.com
Naringenin chemically known as 5, 7-dihydroxy-2-(4-hydroxyphenyl) chroman-4-one is a
common dietary polyphenolic constituent of the citrus fruits. It has received considerable …

BH3-only protein BIM: an emerging target in chemotherapy

S Shukla, S Saxena, BK Singh, P Kakkar - European journal of cell biology, 2017 - Elsevier
BH3-only proteins constitute major proportion of pro-apoptotic members of B-cell lymphoma
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …

[HTML][HTML] Mitochondria-targeted platinum (II) complexes induce apoptosis-dependent autophagic cell death mediated by ER-stress in A549 cancer cells

FY Wang, XM Tang, X Wang, KB Huang… - European Journal of …, 2018 - Elsevier
Agents with multiple modes of tumor cell death can be effective chemotherapeutic drugs.
One example of a bimodal chemotherapeutic approach is an agent that can induce both …

Effect of crocin and naringenin supplementation in cryopreservation medium on post-thaw rooster sperm quality and expression of apoptosis associated genes

M Mehdipour, H Daghigh Kia, A Najafi, H Mohammadi… - Plos one, 2020 - journals.plos.org
The aim of our study was to examine the effects of crocin (0.5 (C0. 5), 1 (C1) and 1.5 (C1. 5)
mM) and naringenin (50 (N50), 100 (N100) and 150 (N150) μM) in cryopreservation …

Flavonoids modulate tight junction barrier functions in hyperglycemic human intestinal Caco-2 cells

S Sharma, P Tripathi, J Sharma, A Dixit - Nutrition, 2020 - Elsevier
Objectives: Diabetes mellitus is a chronic disease requiring lifelong medical attention. With
hundreds of millions suffering worldwide and a rapidly rising incidence, diabetes mellitus …

[HTML][HTML] Naringenin accords hepatoprotection from streptozotocin induced diabetes in vivo by modulating mitochondrial dysfunction and apoptotic signaling cascade

R Kapoor, P Kakkar - Toxicology reports, 2014 - Elsevier
Diabetic complications cause noticeable liver damage, which finally progresses to diabetic
hepatopathy. Nutritive antioxidants not only reduce the liver damage, but also prevent it by …