[HTML][HTML] Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

Z Li, YX Zhu, LJ Gu, Y Cheng - Zoological research, 2021 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills
and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental …

Symptomatic, genetic, and mechanistic overlaps between autism and Alzheimer's disease

MS Nadeem, S Hosawi, S Alshehri, MM Ghoneim… - Biomolecules, 2021 - mdpi.com
Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are neurodevelopmental and
neurodegenerative disorders affecting two opposite ends of life span, ie, childhood and old …

A chromosome-level reference genome and pangenome for barn swallow population genomics

S Secomandi, GR Gallo, M Sozzoni, A Iannucci… - Cell reports, 2023 - cell.com
Insights into the evolution of non-model organisms are limited by the lack of reference
genomes of high accuracy, completeness, and contiguity. Here, we present a chromosome …

Avian models for brain mechanisms underlying altered social behavior in autism

A Csillag, Á Ádám, G Zachar - Frontiers in physiology, 2022 - frontiersin.org
The current review is an update on experimental approaches in which birds serve as model
species for the investigation of typical failure symptoms associated with autism spectrum …

Social stress under binge-like alcohol withdrawal in adolescence: evidence of cannabidiol effect on maladaptive plasticity in rats

A Brancato, V Castelli, G Lavanco, C D'Amico… - Psychological …, 2023 - cambridge.org
BackgroundAlcohol binge drinking may compromise the functioning of the nucleus
accumbens (NAc), ie the neural hub for processing reward and aversive responses …

FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatement

N Khandelwal, A Kulkarni, NI Ahmed, M Harper… - Science …, 2024 - science.org
Long-range glutamatergic inputs originating from the cortex and thalamus are indispensable
for striatal development, providing the foundation for motor and cognitive functions. Despite …

Induction of an immortalized songbird cell line allows for gene characterization and knockout by CRISPR-Cas9

MT Biegler, O Fedrigo, P Collier, J Mountcastle… - Scientific Reports, 2022 - nature.com
The zebra finch is one of the most commonly studied songbirds in biology, particularly in
genomics, neuroscience and vocal communication. However, this species lacks a robust cell …

How thermal challenges change gene regulation in the songbird brain and gonad: Implications for sexual selection in our changing world

SE Lipshutz, CR Howell, AM Buechlein… - Molecular …, 2022 - Wiley Online Library
In a rapidly warming world, exposure to high temperatures may impact fitness, but the gene
regulatory mechanisms that link sublethal heat to sexually selected traits are not well …

Auditory discrimination learning and acoustic cue weighing in female zebra finches with localized FoxP1 knockdowns

F Heim, C Scharff, SE Fisher… - Journal of …, 2024 - journals.physiology.org
Rare disruptions of the transcription factor FOXP1 are implicated in a human
neurodevelopmental disorder characterized by autism and/or intellectual disability with …

Effects of cortical FoxP1 knockdowns on learned song preference in female zebra finches

F Heim, SE Fisher, C Scharff, C Ten Cate, K Riebel - eneuro, 2023 - eneuro.org
The search for molecular underpinnings of human vocal communication has focused on
genes encoding forkhead-box transcription factors, as rare disruptions of FOXP1, FOXP2 …