The element selenium was discovered in 1818 by the Swedish chemist Berzelius and was
named after the Greek goddess of the moon, Selene. 1 In biology, selenium was long …

Many excellent and up to date reviews on kinase inhibitors exist, and this area certainly
does not meet the normal criteria for a Chemical Reviews article. However, most of these …

4-(3-Bromoanilino)-6, 7-dimethoxyquinazoline (32, PD 153035) is a very potent inhibitor
(IC50 0.025 nM) of the tyrosine kinase activity of the epidermal growth factor receptor …

Receptor tyrosine kinases (RTKs) are the main mediators of the signaling network that
transmit extracellular signals into the cell, and control cellular differentiation and …

Alkyl, aryl and heteroaryl symmetrical disulfides can be easily obtained by heating the
corresponding thiols for several hours at 80° C with Et3N in DMF under atmospheric oxygen …

Classifying kinases based entirely on small molecule selectivity data is a new approach to
drug discovery that allows scientists to understand relationships between targets. This …

Inhibitors for tyrosine-specific protein kinases ultimately may constitute a novel family of
medicinally active agents. Unfortunately, the challenges associated with the acquisition of …

Organochalcogen compounds (containing S, Se and Te) are interesting either for use as an
intermediate in the synthesis of complex molecules or for the exploitation of their biological …

The synthesis of 7-aminopyrido [4, 3-d] pyrimidines bearing aromatic side chains at the 4-
position is reported. These compounds are shown to be a new class of inhibitors of the …

Following the discovery of the very high inhibitory ability of the 4-[(3-bromophenyl) amino]
quinazolines against the tyrosine kinase activity of the epidermal growth factor receptor …