There is nervous control of the heart by ATP as a cotransmitter in sympathetic,
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …

Calcium is an important second messenger required not only for the excitation-contraction
coupling of the heart but also critical for the activation of cell signaling pathways involved in …

Cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac
fibroblasts and myofibroblasts, and is a hallmark feature of most heart diseases, including …

Cardiac fibroblasts make up a major proportion of non-excitable cells in the heart and
contribute to the cardiac structural integrity and maintenance of the extracellular matrix …

Diabetic cardiomyopathy (DCM) is a complication of diabetes mellitus which result in cardiac
remodeling and subsequent heart failure. However, the role of P2X7 receptor (P2X7R) in …

Transient receptor potential vanilloid subtype 1 (TRPV1) is a polymodal nociceptor that
monitors noxious thermal sensations. Few studies have addressed the role of TRPV1 in …

In whole-cell voltage clamped bovine adrenal chromaffin cells maintained at a holding
potential of− 70 mV, a single 5 ns, 5 MV/m pulse elicited an inward current carried mainly by …

Sustained pressure overload and fibrosis of the right ventricle (RV) are the leading causes of
mortality in pulmonary arterial hypertension (PAH). Although the role of adenosine in PAH …

Specialized microdomains which have cholesterol-rich membrane regions contain transient
receptor potential vanilloid subtype 1 (TRPV1) are involved in pain development. Our …

Extracellular adenosine diphosphate (ADP) mediates a wide range of physiological effects
as an extracellular signaling molecule, including platelet aggregation, vascular tone, cell …