Introduction: Although n-3 polyunsaturated fatty acids have been widely described as
antiinflammatory fats, little is known about the role of oleic acid in immune system. Aim: The …

Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of Ca 2+ stores within the endoplasmic reticulum (ER) and contributes …

The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …

Lipid rafts, the sphingolipid and cholesterol-enriched membrane microdomains, are able to
form different membrane macrodomains or platforms upon stimulations, including redox …

STIM1 (stromal interaction molecule 1) and Orai proteins are the essential components of
Ca2+ release–activated Ca2+ (CRAC) channels. We focused on the role of cholesterol in …

Cholesterol is an essential structural component of cellular membranes. In addition to the
structural role, it also serves as a precursor to a variety of steroid hormones and has diverse …

We have previously shown that PIP5KIβ and PIP5KIγ generate functionally distinct pools of
phosphatidylinositol 4, 5-bisphosphate [PtdIns (4, 5) P 2] important for antigen-stimulated …

Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …

Globoid cell leukodystrophy (GLD) is a metabolic disease caused by mutations in the
galactocerebrosidase (GALC) gene. GALC is a lysosomal enzyme whose function is to …

Sterols are a critical component of cell membranes of eukaryotes. In mammalian cells there
is approximately a six-fold range in the cholesterol content in various organelles. The …