Levetiracetam mechanisms of action: from molecules to systems
IJ Contreras-García, N Cárdenas-Rodríguez… - Pharmaceuticals, 2022 - mdpi.com
Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …
Synaptic vesicle glycoprotein 2A: features and functions
In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …
expeditious development of specific radioligands of novel targets. Among these targets, the …
[HTML][HTML] The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves
S Mahrhold, A Rummel, H Bigalke, B Davletov, T Binz - FEBS letters, 2006 - Elsevier
Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release by selectively cleaving core
components of the vesicular fusion machinery. The synaptic vesicle proteins Synaptotagmin …
components of the vesicular fusion machinery. The synaptic vesicle proteins Synaptotagmin …
Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
A Yamagata, K Ito, T Suzuki, N Dohmae… - Nature …, 2024 - nature.com
More than one percent of people have epilepsy worldwide. Levetiracetam (LEV) is a
successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV) …
successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV) …
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease
Members of the synaptic vesicle glycoprotein 2 (SV2) family of proteins are involved in
synaptic function throughout the brain. The ubiquitously expressed SV2A has been widely …
synaptic function throughout the brain. The ubiquitously expressed SV2A has been widely …
Synaptic vesicle protein 2 enhances release probability at quiescent synapses
KL Custer, NS Austin, JM Sullivan… - Journal of …, 2006 - Soc Neuroscience
We report a thorough analysis of neurotransmission in cultured hippocampal neurons
lacking synaptic vesicle protein 2 (SV2), a membrane glycoprotein present in all vesicles …
lacking synaptic vesicle protein 2 (SV2), a membrane glycoprotein present in all vesicles …
The synaptic vesicle glycoprotein 2: structure, function, and disease relevance
The synaptic vesicle glycoprotein 2 (SV2) family is comprised of three paralogues: SV2A,
SV2B, and SV2C. In vertebrates, SV2s are 12-transmembrane proteins present on every …
SV2B, and SV2C. In vertebrates, SV2s are 12-transmembrane proteins present on every …
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry
The unique nerve terminal targeting of botulinum neurotoxin type A (BoNT/A) is due to its
capacity to bind two receptors on the neuronal plasma membrane: polysialoganglioside …
capacity to bind two receptors on the neuronal plasma membrane: polysialoganglioside …
Puzzling out synaptic vesicle 2 family members functions
O Bartholome, P Van den Ackerveken… - Frontiers in molecular …, 2017 - frontiersin.org
Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear
demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam …
demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam …
SV2 renders primed synaptic vesicles competent for Ca2+-induced exocytosis
WP Chang, TC Südhof - Journal of Neuroscience, 2009 - Soc Neuroscience
Synaptic vesicle protein 2 (SV2), one of the first synaptic vesicle proteins identified, is
characterized by multiple transmembrane regions that exhibit homology to sugar …
characterized by multiple transmembrane regions that exhibit homology to sugar …