This review examines the use of Caco-2 monolayers in the prediction of intestinal drug
absorption. First, the different routes of drug transport in Caco-2 monolayers are compared …

The antituberculosis drug rifampicin (rifampin) induces a number of drug-metabolising
enzymes, having the greatest effects on the expression of cytochrome P450 (CYP) 3A4 in …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

Drugs may be administered via different routes, the oral route generally being the preferred
for reasons of ease and compliance by the patient. Absorption via these routes will take …

This study reports on a novel, high-throughput assay, designed to predict passive,
transcellular permeability in early drug discovery. The assay is carried out in 96-well …

Many orally administered drugs must overcome several barriers before reaching their target
site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic …

Abstract□ This review focuses on permeability measurements in humans, briefly discussing
different perfusion techniques, the relevance of human P eff values, and various aspects of …

A recently developed, new theoretical absorption model for passive diffusion through
biological membranes describing the dependency of membrane permeability on lipophilicity …

The efflux transporter, P-glycoprotein (P-gp), located in the apical membranes of intestinal
absorptive cells, can reduce the bioavailability of a wide range of orally administered drugs …

The primary function of the small intestine is to absorb nutrients and water. This is achieved
by mixing food with digestive enzymes to increase the contact of foodstuffs with the …