Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

This review summarizes our current knowledge of human disease-relevant genetic variants
within the family of voltage gated Ca2+ channels. Ca2+ channelopathies cover a wide …

In the heart, reliable activation of Ca2+ release from the sarcoplasmic reticulum during the
plateau of the ventricular action potential requires synchronous opening of multiple CaV1. 2 …

Timothy Syndrome (TS) is a multisystem disorder, prominently featuring cardiac action
potential prolongation with paroxysms of life-threatening arrhythmias. The underlying defect …

The voltage-gated L-type calcium channel (LTCC) is essential for multiple cellular
processes. In the heart, calcium influx through LTCC plays an important role in cardiac …

Key points Prevailing dogma holds that activation of the β‐adrenergic receptor/cAMP/protein
kinase A signalling pathway leads to enhanced L‐type CaV1. 2 channel activity, resulting in …

Aims MicroRNAs (miRNAs) are crucial for the post-transcriptional control of protein-
encoding genes and together with transcription factors (TFs) regulate gene expression; …

Microtubules (MTs) have many roles in ventricular myocytes, including structural stability,
morphological integrity, and protein trafficking. However, despite their functional importance …

Aims Impaired Ca2+ cycling and myocyte contractility are a hallmark of heart failure
triggered by pathological stress such as hemodynamic overload. The A-Kinase anchoring …

The CACNA1C gene encodes the pore-forming subunit of the CaV1. 2 L-type Ca2+ channel,
a critical component of membrane physiology in multiple tissues, including the heart, brain …