Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Severe or life threatening infections are common among patients in the intensive care unit
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …

Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …

Summary Background In February, 2017, the US Food and Drug Administration approved
the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute …

Background In critically ill patients, antibiotic therapy is of great importance but long duration
of treatment is associated with the development of antimicrobial resistance. Procalcitonin is …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …

Sepsis is a life-threatening organ dysfunction that results from the body's response to
infection. It requires prompt recognition, appropriate antibiotics, careful hemodynamic …

Background Procalcitonin (PCT)-guided antibiotic stewardship (ABS) has been shown to
reduce antibiotics (ABxs), with lower side-effects and an improvement in clinical outcomes …

Background. The value of rapid, panel-based molecular diagnostics for positive blood
culture bottles (BCBs) has not been rigorously assessed. We performed a prospective …