Droplet microfluidics has revolutionized the study of single cells. The ability to
compartmentalize cells within picoliter droplets in microfluidic devices has opened up a wide …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences …

Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

Individual mammalian cells exhibit large variability in cellular volume, even with the same
absolute DNA content, and so must compensate for differences in DNA concentration in …

The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of
genomic loci. Recent work suggested that rather than up-and downregulating selected …

Aging is associated with reduced fitness and increased myeloid bias of the hematopoietic
stem cell (HSC) compartment, causing increased risk of immune compromise, anemia, and …

A central question in biology is whether variability between genetically identical cells
exposed to the same culture conditions is largely stochastic or deterministic. Using image …

The ability to quantify differentiation potential of single cells is a task of critical importance.
Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation …

Genetically identical cells grown in the same culture display striking cell-to-cell
heterogeneity in gene expression and other traits. A crucial challenge is to understand how …