Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

The stress response is an essential mechanism for maintaining homeostasis, and its
disruption is implicated in several psychiatric disorders. On the cellular level, stress …

The precise regulation of gene expression is fundamental to neurodevelopment, plasticity
and cognitive function. Although several studies have profiled transcription in the developing …

Abstract Calcineurin (CaN), a Ca2+/calmodulin-activated serine/threonine phosphatase,
acts as a Ca2+-sensitive switch regulating cellular functions through protein …

Electroacupuncture (EA) has been widely used for functional restoration after stroke.
However, its role in post-stroke rehabilitation and the associated regulatory mechanisms …

Introduction Current treatments for psychosis in Alzheimer's disease (AD), a syndrome
characterized by more rapid deterioration and reduced synaptic protein abundance relative …

Huntington's disease (HD) is an inherited neurodegenerative disorder, caused by an
abnormal polyglutamine (polyQ) expansion in the huntingtin protein (Htt). Mitochondrial …

Neurotransmitters are generated by de novo synthesis and are essential for sustained, high-
frequency synaptic transmission. Histamine, a monoamine neurotransmitter, is synthesized …

In human neurodegenerative diseases, neurons undergo axonal degeneration months to
years before they die. Here, we developed a system modeling early degenerative events in …

Behavioral and psychotic manifestations, including aggression, delusions, and
hallucinations, are frequent comorbidities in patients with debilitating nervous illnesses such …