Myelin basic protein—diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis
G Harauz, N Ishiyama, CMD Hill, IR Bates, DS Libich… - Micron, 2004 - Elsevier
The 18.5 kDa isoform of myelin basic protein (MBP) is a major component of the myelin
sheath in the central nervous system of higher vertebrates, and a member of a larger family …
sheath in the central nervous system of higher vertebrates, and a member of a larger family …
MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis
KA Vassall, VV Bamm, G Harauz - Biochemical Journal, 2015 - portlandpress.com
The classic isoforms of myelin basic protein (MBP, 14–21.5 kDa) are essential to formation
of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The …
of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The …
Membrane-anchoring and charge effects in the interaction of myelin basic protein with lipid bilayers studied by site-directed spin labeling
IR Bates, JM Boggs, JB Feix, G Harauz - Journal of Biological Chemistry, 2003 - ASBMB
Myelin basic protein (MBP) maintains the compaction of the myelin sheath in the central
nervous system by anchoring the cytoplasmic face of the two apposing bilayers and may …
nervous system by anchoring the cytoplasmic face of the two apposing bilayers and may …
The classic basic protein of myelin-conserved structural motifs and the dynamic molecular barcode involved in membrane adhesion and protein-protein interactions
G Harauz, DS Libich - Current Protein and Peptide Science, 2009 - ingentaconnect.com
The myelin basic protein (MBP) family comprises a variety of developmentally-regulated
members arising from different transcription start sites, differential splicing, and post …
members arising from different transcription start sites, differential splicing, and post …
[HTML][HTML] Exploring intrinsic disorder in human synucleins and associated proteins
SR Venati, VN Uversky - International Journal of Molecular Sciences, 2024 - mdpi.com
In this work, we explored the intrinsic disorder status of the three members of the synuclein
family of proteins—α-, β-, and γ-synucleins—and showed that although all three human …
family of proteins—α-, β-, and γ-synucleins—and showed that although all three human …
An immunodominant epitope of myelin basic protein is an amphipathic α-helix
IR Bates, JB Feix, JM Boggs, G Harauz - Journal of Biological Chemistry, 2004 - ASBMB
Myelin basic protein is a candidate autoantigen in multiple sclerosis. One of its dominant
antigenic epitopes is segment Pro 85 to Pro 96 (human sequence numbering …
antigenic epitopes is segment Pro 85 to Pro 96 (human sequence numbering …
Structured functional domains of myelin basic protein: Cross talk between actin polymerization and Ca2+-dependent calmodulin interaction
VV Bamm, M De Avila, GST Smith, MAM Ahmed… - Biophysical journal, 2011 - cell.com
Abstract The 18.5-kDa myelin basic protein (MBP), the most abundant isoform in human
adult myelin, is a multifunctional, intrinsically disordered protein that maintains compact …
adult myelin, is a multifunctional, intrinsically disordered protein that maintains compact …
Backbone dynamics of the 18.5 kDa isoform of myelin basic protein reveals transient α-helices and a calmodulin-binding site
DS Libich, G Harauz - Biophysical journal, 2008 - cell.com
The 18.5 kDa isoform of myelin basic protein (MBP) is the predominant form in adult human
central nervous system myelin. It is an intrinsically disordered protein that functions both in …
central nervous system myelin. It is an intrinsically disordered protein that functions both in …
Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5‐kDa myelin basic protein decrease its affinity for the Fyn‐SH3 domain and alter …
GST Smith, M De Avila, PM Paez… - Journal of …, 2012 - Wiley Online Library
The developmentally regulated myelin basic proteins (MBPs), which arise from the golli
(gene of oligodendrocyte lineage) complex, are highly positively charged, intrinsically …
(gene of oligodendrocyte lineage) complex, are highly positively charged, intrinsically …
Assembly of tubulin by classic myelin basic protein isoforms and regulation by post-translational modification
CMD Hill, DS Libich, G Harauz - Biochemistry, 2005 - ACS Publications
Myelin basic protein (MBP), a highly cationic protein that maintains the structure of the
myelin sheath, associates with tubulin in vivo. The in vitro assembly of tubulin by MBP was …
myelin sheath, associates with tubulin in vivo. The in vitro assembly of tubulin by MBP was …