Cells in focus: endothelial cell
The endothelial cell is thought to arise from the splanchnopleuric mesoderm. Endothelial
cells form the inner lining of a blood vessel and provides an anticoagulant barrier between …
cells form the inner lining of a blood vessel and provides an anticoagulant barrier between …
Thrombomodulin in disseminated intravascular coagulation and other critical conditions—a multi-faceted anticoagulant protein with therapeutic potential
Thrombomodulin plays a vital role in maintaining intravascular patency due to its
anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological …
anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological …
Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs
Background Thromboembolism is a life-threatening manifestation of coronavirus disease
2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells …
2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells …
[HTML][HTML] KLF2 and KLF4 control endothelial identity and vascular integrity
Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically
dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow …
dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow …
Endothelial cell recovery between comparator polymer-based drug-eluting stents
Objectives: The purpose of this study was to assess trends in endothelial coverage and
recovery among leading polymer-based drug-eluting stents (DES). Background: Autopsy …
recovery among leading polymer-based drug-eluting stents (DES). Background: Autopsy …
[HTML][HTML] Spatial and temporal dynamics of the endothelium
WC Aird - Journal of thrombosis and haemostasis, 2005 - Elsevier
The endothelium is a highly metabolically active organ that is involved in many physiological
processes, including the control of vasomotor tone, barrier function, leukocyte adhesion and …
processes, including the control of vasomotor tone, barrier function, leukocyte adhesion and …
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
Data providing direct evidence for a causative link between endothelial dysfunction,
microvascular disease and diabetic end-organ damage are scarce. Here we show that …
microvascular disease and diabetic end-organ damage are scarce. Here we show that …
PAMPs and DAMPs as triggers for DIC
T Ito - Journal of intensive care, 2014 - Springer
Thrombosis is generally considered harmful because it compromises the blood supply to
organs. However, recent studies have suggested that thrombosis under certain …
organs. However, recent studies have suggested that thrombosis under certain …
[HTML][HTML] Thrombomodulin
H Weiler, BH Isermann - Journal of thrombosis and haemostasis, 2003 - Elsevier
Since its discovery as a critical cofactor in the initiation of the protein C (PC) anticoagulant
pathway [1, 2], biochemical and structural investigations, combined with in vivo analyses of …
pathway [1, 2], biochemical and structural investigations, combined with in vivo analyses of …
Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects
FA Martin, RP Murphy… - American Journal of …, 2013 - journals.physiology.org
Thrombomodulin (TM) is a 557-amino acid protein with a broad cell and tissue distribution
consistent with its wide-ranging physiological roles. When expressed on the lumenal surface …
consistent with its wide-ranging physiological roles. When expressed on the lumenal surface …