Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …

Epigenetic alterations, along with genetic alterations, have long been regarded as the most
important mechanism participating in carcinogenesis. DNA methylation, histone …

B cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2
histone methyltransferase (EZH2), but the carcinogenic role of these mutations is unclear …

Introduction Posttranslational modification of histones is a well-documented mechanism by
which the chromatin structure is modulated to regulate gene expression. Increasing …

Myocardial ischemia has a high incidence and mortality rate, and reperfusion is currently the
standard intervention. However, reperfusion may lead to further myocardial damage, known …

Maternal exposures to environmental factors during pregnancy influence the risk of many
chronic adult-onset diseases in the offspring. Here we investigate whether feeding pregnant …

Abstract Caveolin-1 (Cav1) is an integral membrane, scaffolding protein found in plasma
membrane invaginations (caveolae). Cav1 regulates multiple cancer-associated processes …

Hepatocellular carcinomas (HCC) exhibit distinct promoter hypermethylation patterns, but
the epigenetic regulation and function of transcriptional enhancers remain unclear. Here …

Many researchers have speculated that the clinical progression from monoclonal
gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) is driven by …