Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH
is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The …

The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

Sarcomas are a biologically complex group of tumors of mesenchymal origin. By using gene
expression microarray analysis, we aimed to find clues into the cellular differentiation and …

Activin was discovered in the 1980's as a gonadal protein that stimulated FSH release from
pituitary gonadotropes and was thought of as a reproductive hormone. In the ensuing …

Self-renewal is a defining characteristic of stem cells; however, the molecular pathways
underlying its regulation are poorly understood. Here, we demonstrate that conditional …

TALE (three amino acids loop extension) homeodomain transcription factors are required in
various steps of embryo development, in many adult physiological functions, and are …

The precise interplay of hormonal influences that governs gonadotropin hormone production
by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic …

The pituitary gonadotropin hormones, FSH and LH, are key regulators of reproductive
physiology. Though the two hormones are produced by the same cell type, often in response …

The pituitary gland is an important component of the endocrine system, and together with the
hypothalamus, exerts considerable influence over the functions of other endocrine glands …

Reproductive function in mammals is regulated by the pituitary gonadotropins luteinizing
hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are secreted by the …