Modern molecular genetic and genomic approaches are revolutionizing the study of
behavior in the mouse." Reverse genetics"(from gene to phenotype) with targeted gene …

γ-Aminobutyric acid (GABA), acting at GABAA receptors, mediates inhibition in inferior
colliculus (IC) central nucleus (ICc) neurons and plays a prominent role in mediating …

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …

The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for
primary hypertension in humans. High blood pressure in SHRSP shows polygenic …

Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum
disorder (ASD). However, the role of a major pathway controlling protein synthesis, the …

The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related
neurotrophins. Here we present a developmental expression study of trk C, which encodes a …

Alcohol dependence (alcoholism) is accompanied by evidence of tolerance, withdrawal
(physiological dependence), or compulsive behavior related to alcohol use. Studies of strain …

Frings mice are a model of generalized epilepsy and have seizures in response to loud
noises. This phenotype is due to the autosomal recessive inheritance of a single gene on …

DBA/2J (D2) and C57BL/6J (B6) mice exhibit differential sensitivity to seizures induced by
various chemical and physical methods, with D2 mice being relatively sensitive and B6 mice …

The epilepsies are a heterogeneous collection of seizure disorders with a lifetime
expectancy risk rate of 2–4% 1. A convergence of evidence indicates that heritable factors …