Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses
KL Hilligan, F Ronchese - Cellular & molecular immunology, 2020 - nature.com
Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules
Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …
immune response. They have evolved a spectrum of immunomodulatory molecules that are …
T helper cell differentiation, heterogeneity, and plasticity
J Zhu - Cold Spring Harbor perspectives in biology, 2018 - cshperspectives.cshlp.org
Naïve CD4 T cells, on activation, differentiate into distinct T helper (Th) subsets that produce
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …
[HTML][HTML] Recent advances in understanding the Th1/Th2 effector choice
MJ Butcher, J Zhu - Faculty reviews, 2021 - ncbi.nlm.nih.gov
For over 35 years since Mosmann and Coffman proposed the seminal “type 1 T helper
(Th1)/type 2 T helper (Th2)” hypothesis in 1986, the immunological community has …
(Th1)/type 2 T helper (Th2)” hypothesis in 1986, the immunological community has …
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4+ T cells potentiates type 2 immunity and promotes parasitic helminth expulsion
CJ Oliphant, YY Hwang, JA Walker, M Salimi, SH Wong… - Immunity, 2014 - cell.com
Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective
immunity to helminth infection and detrimentally during allergy and asthma. Using two …
immunity to helminth infection and detrimentally during allergy and asthma. Using two …
T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production
J Zhu - Cytokine, 2015 - Elsevier
Abstract Interleukin-4 (IL-4), IL-5 and IL-13, the signature cytokines that are produced during
type 2 immune responses, are critical for protective immunity against infections of …
type 2 immune responses, are critical for protective immunity against infections of …
Helminth infections and host immune regulation
HJ McSorley, RM Maizels - Clinical microbiology reviews, 2012 - Am Soc Microbiol
Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …
regions. However, regions where helminth parasites are endemic record much lower …
Diversity and dialogue in immunity to helminths
JE Allen, RM Maizels - Nature Reviews Immunology, 2011 - nature.com
The vertebrate immune system has evolved in concert with a broad range of infectious
agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth …
agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth …
Schistosoma “eggs-iting” the host: granuloma formation and egg excretion
C Schwartz, PG Fallon - Frontiers in immunology, 2018 - frontiersin.org
Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with
parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle …
parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle …
How are TH2-type immune responses initiated and amplified?
WE Paul, J Zhu - Nature reviews immunology, 2010 - nature.com
Abstract CD4+ T helper (TH) cells have crucial roles in orchestrating adaptive immune
responses. TH2 cells control immunity to extracellular parasites and all forms of allergic …
responses. TH2 cells control immunity to extracellular parasites and all forms of allergic …