Tick-borne encephalitis (TBE) is an illness caused by tick-borne encephalitis virus (TBEV)
infection which is often limited to a febrile illness, but may lead to very aggressive …

The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …

Nucleoside analogs represent the largest class of small molecule-based antivirals, which
currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis …

The search for new drugs has been greatly accelerated by the emergence of new viruses
and drug-resistant strains of known pathogens. Nucleoside analogues (NAs) are a …

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted great interest in novel …

Antiviral action of various photosensitizers is already summarized in several comprehensive
reviews, and various mechanisms have been proposed for it. However, a critical …

Rigid amphipathic fusion inhibitors (RAFIs) are a family of nucleoside derivatives that inhibit
the infectivity of several enveloped viruses by interacting with virion envelope lipids and …

Perylenylethynyl derivatives have been recognized as broad-spectrum antivirals that target
the lipid envelope of enveloped viruses. In this study, we present novel …

Amphipathic nucleoside and non-nucleoside derivatives of pentacyclic aromatic
hydrocarbon perylene are known as potent non-cytotoxic broad-spectrum antivirals. Here …

Most antivirals target viral proteins and are specific for only one virus, or viral type. Whereas
viral proteins are encoded in the plastic viral genome, virion lipids are not and their …