Thyroid transcription factors in development, differentiation and disease

LP Fernandez, A Lopez-Marquez… - Nature Reviews …, 2015 - nature.com
Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX,
has considerably advanced our understanding of thyroid development, congenital thyroid …

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

SM Gough, CI Slape, PD Aplan - Blood, The Journal of the …, 2011 - ashpublications.org
Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily
balanced translocations and inversions, are associated with a wide array of hematopoietic …

Phase separation drives aberrant chromatin looping and cancer development

JH Ahn, ES Davis, TA Daugird, S Zhao, IY Quiroga… - Nature, 2021 - nature.com
The development of cancer is intimately associated with genetic abnormalities that target
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies …

Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies

NL Michmerhuizen, JM Klco… - Blood, The Journal of …, 2020 - ashpublications.org
Abstract Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of
hematologic malignancies, particularly pediatric leukemias with poor patient outcomes …

Nuclear pore proteins and cancer

S Xu, MA Powers - Seminars in cell & developmental biology, 2009 - Elsevier
Nucleocytoplasmic trafficking of macromolecules, a highly specific and tightly regulated
process, occurs exclusively through the nuclear pore complex. This immense structure is …

Direct and indirect targeting of HOXA9 transcription factor in acute myeloid leukemia

M Lambert, M Alioui, S Jambon, S Depauw… - Cancers, 2019 - mdpi.com
HOXA9 (Homeobox A9) is a homeotic transcription factor known for more than two decades
to be associated with leukemia. The expression of HOXA9 homeoprotein is associated with …

Role of the nuclear envelope in genome organization and gene expression

DW Van de Vosse, Y Wan, RW Wozniak… - … Systems Biology and …, 2011 - Wiley Online Library
Although often depicted as a static structure upon which proteinaceous factors bind to
control gene expression, the genome is actually highly mobile and capable of exploring the …

GATA-2 reinforces megakaryocyte development in the absence of GATA-1

Z Huang, LC Dore, Z Li, SH Orkin, G Feng… - … and cellular biology, 2009 - Taylor & Francis
GATA-2 is an essential transcription factor that regulates multiple aspects of hematopoiesis.
Dysregulation of GATA-2 is a hallmark of acute megakaryoblastic leukemia in children with …

The Haematopoietically-expressed homeobox transcription factor: roles in development, physiology and disease

JT Jackson, SL Nutt, MP McCormack - Frontiers in Immunology, 2023 - frontiersin.org
The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional
repressor that is of fundamental importance across species, as evident by its evolutionary …

Multilevel view on chromatin architecture alterations in cancer

M Gridina, V Fishman - Frontiers in Genetics, 2022 - frontiersin.org
Chromosomes inside the nucleus are not located in the form of linear molecules. Instead,
there is a complex multilevel genome folding that includes nucleosomes packaging …