Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX,
has considerably advanced our understanding of thyroid development, congenital thyroid …

Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily
balanced translocations and inversions, are associated with a wide array of hematopoietic …

The development of cancer is intimately associated with genetic abnormalities that target
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies …

Abstract Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of
hematologic malignancies, particularly pediatric leukemias with poor patient outcomes …

Nucleocytoplasmic trafficking of macromolecules, a highly specific and tightly regulated
process, occurs exclusively through the nuclear pore complex. This immense structure is …

HOXA9 (Homeobox A9) is a homeotic transcription factor known for more than two decades
to be associated with leukemia. The expression of HOXA9 homeoprotein is associated with …

Although often depicted as a static structure upon which proteinaceous factors bind to
control gene expression, the genome is actually highly mobile and capable of exploring the …

GATA-2 is an essential transcription factor that regulates multiple aspects of hematopoiesis.
Dysregulation of GATA-2 is a hallmark of acute megakaryoblastic leukemia in children with …

The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional
repressor that is of fundamental importance across species, as evident by its evolutionary …

Chromosomes inside the nucleus are not located in the form of linear molecules. Instead,
there is a complex multilevel genome folding that includes nucleosomes packaging …