The use of effective regimens for mitigating pain remain underutilized in research rodents
despite the general acceptance of both the ethical imperative and regulatory requirements …

A potential cause of suffering in animal experimentation is pain induced by procedures,
diseases, and injuries. Pain is not only nociception, the sensory nervous system's response …

Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the
pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory …

An adequate analgesic strategy is important to improve the postoperative recovery and
welfare of laboratory rats and mice. It is desirable that the method for administering the drug …

Establishing effective cage-side pain assessment methods is essential if post-surgical pain
is to be controlled effectively in laboratory animals. Changes to overall activity levels are the …

This study investigated the effects of surgical placement of permanent arterial catheters on
plasma corticosterone levels, fecal corticosterone excretion and body weight in male …

Complete Freund's adjuvant (CFA)-induced arthritis in rats is a common animal model for
studying chronic inflammatory pain. However, modelling of the disease is associated with …

In all animal species that have been studied, pain is underdiagnosed and undertreated, and
pain is undertreated even when veterinarians identify that it is likely to be present. 1–3 In …

Buprenorphine, an analgesic commonly used in rodent surgery, requires repeated dosing
every 4 to 6 h in order to provide adequate analgesia. However, redosing requires repeated …

Effective pain management for rats and mice is crucial due to the continuing increase in the
use of these species in biomedical research. Here we used a recently validated operant …