The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

The genetic underpinnings and end-stage pathological hallmarks of neurodegenerative
diseases are increasingly well defined, but the cellular pathophysiology of disease initiation …

INTRODUCTION The nuclear pore complex (NPC) is the molecular conduit in the nuclear
membrane of eukaryotic cells that regulates import and export of biomolecules between the …

Proximity-dependent biotin identification (BioID) is a method for identifying protein
associations that occur in vivo. By fusing a promiscuous biotin ligase to a protein of interest …

Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic
leukemia (B-ALL) with alteration of IKZF1, a gene expression profile similar to BCR-ABL1 …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

We present a thorough analysis of nuclear export signals and a prediction server, which we
have made publicly available. The machine learning prediction method is a significant …

CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a
member of the importin β superfamily of nuclear transport receptors, recognizing proteins …

HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving
functional interactions between the capsid protein (CA) and nucleoporins (Nups). Here, we …

Nuclear pore complexes (NPCs) are channels for nucleocytoplasmic transport of proteins
and RNAs. However, it remains unclear whether composition, structure, and permeability of …