The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic
adaptor proteins regulate the signal transduction pathways of a variety of receptors …

Abstract Purpose of Review This review presents an overview of the current knowledge of
tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) molecules in inflammation …

Background Urothelial carcinoma (UC) is the most common pathological type of bladder
cancer, a malignant tumor. However, an integrated multi-omics analysis of the Chinese UC …

The TNFR superfamily of receptors, the major focus of the recent TNFR Superfamily
Conference held in June 2019, employ the TNFR-associated factor (TRAF) family of adaptor …

Abstract CD4+ T helper cells (TH cells), such as TH 1, TH 2, TH 17, T FH, and T reg cells,
play critical roles in host defense against infection and in the pathogenesis of immune …

Tumor necrosis factor receptor-associated factors (TRAFs) are signaling mediators for Toll-
like receptor (TLR) and tumor necrosis factor (TNFR) superfamily that play important roles in …

Generation and maintenance of antigen-specific effector and memory T cells are central
events in immune responses against infections. We show that TNF receptor-associated …

Anticancer immune surveillance and immunotherapies trigger activation of cytotoxic cytokine
signaling, including tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing …

Co-stimulatory tumor necrosis factor receptors (TNFRs) can sculpt the responsiveness of T
cells recognizing tumor-associated antigens. For this reason, agonist antibodies targeting …

Aims/hypothesis Administration of anti-CD40 ligand (CD40L) antibodies has been reported
to allow long-term islet allograft survival in non-human primates without the need for …