Reactive oxygen species (ROS) are generated following ligand-receptor interactions and
function as specific second messengers in signaling cascades involved in cell proliferation …

Reactive oxygen species (ROS) have been traditionally regarded as toxic byproducts of
aerobic metabolism. However, ROS can also act as intracellular signaling molecules in …

Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …

Recent progress in single-cell technologies has enabled the identification of all major cell
types in mouse. However, for most cell types, the regulatory mechanism underlying their …

Increased production of reactive oxygen species (ROS) has been implicated in the
pathogenesis of cardiovascular diseases. Enzymatic systems such as the mitochondrial …

Despite our present knowledge of some of the cellular pathways that modulate central
nervous system injury, complete therapeutic prevention or reversal of acute or chronic …

Cooperation among transcription factors is central for their ability to execute specific
transcriptional programmes. The AP1 complex exemplifies a network of transcription factors …

Angiogenesis, a crucial step in tumor growth and metastasis, is regulated by various pro-or
anti-angiogenic factors. Recently, microRNAs have been shown to modulate angiogenic …

Abstract Cellular Jun (c-Jun) and viral Jun (v-Jun) can induce oncogenic transformation. For
this activity, c-Jun requires an upstream signal, delivered by the Jun N-terminal kinase …

The migration of vascular smooth muscle cells (VSMCs) plays an essential role during the
development of atherosclerosis and restenosis. Extensive studies have implicated the …