Organ dysfunction or overt failure is a commonplace event in the critically ill affecting up to
70% of patients during their stay in the ICU. The outcome depends on the resolution of …

Acute clinical deterioration of a patient with chronic liver disease remains a decisive time
point both in terms of medical management and prognosis. This condition, also known as …

Background & Aims Inpatients with cirrhosis have high rates of acute-on-chronic failure
(ACLF) development and high mortality within 30 days of admission to the hospital. Better …

The clinical stages of cirrhosis have traditionally been divided into a compensated phase
with no complications and a decompensated phase that manifests with complications of …

Background & Aims Acute kidney injury (AKI) is a significant clinical event in cirrhosis yet
contemporary population-based studies on the impact of AKI on hospitalized cirrhotics are …

This narrative review addresses the definition of acute‐on‐chronic liver failure, a condition
associated with high short‐term mortality in patients with chronic liver disease and/or …

Background Acute‐on‐chronic liver failure (ACLF) is a clinically and pathophysiologically
distinct condition from acutely decompensated cirrhosis and is characterised by systemic …

Background Multiple predictive models of mortality exist for acute-on-chronic liver failure
(ACLF) patients that often create confusion during decision-making. We studied the natural …

Rationale & Objective The decision to initiate kidney replacement therapy (KRT) for acute
kidney injury (AKI) in cirrhosis remains controversial because it is unclear which patients will …

Acute-on-chronic liver failure (ACLF), a clinical syndrome that can develop at any stage in
the progression of cirrhotic liver disease, is characterized by an acute decompensation in …