Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of
obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in …

Alteration in the composition of the gut microbiota can lead to a number of chronic clinical
diseases. Akkermansia muciniphila is an anaerobic bacteria constituting 3–5% of the gut …

Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal
activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high …

The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …

Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …

Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

Maintaining healthy body weight is increasingly difficult in our obesogenic environment.
Dieting efforts are often overpowered by the internal drive to consume energy-dense foods …

Body weight is regulated by interoceptive neural circuits that track energy need, but how the
activity of these circuits is altered in obesity remains poorly understood. Here we describe …