Like other autoimmune diseases, rheumatoid arthritis (RA) develops in distinct stages, with
each phase of disease linked to immune cell dysfunction. HLA class II genes confer the …

Objectives: To develop evidence-based EULAR recommendations for cardiovascular (CV)
risk management in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and …

Healthy vascular function is primarily regulated by several factors including EDRF
(endothelium-dependent relaxing factor), EDCF (endothelium-dependent contracting factor) …

Objective To determine the efficacy, safety, and tolerability of 3 different dosages of CP‐
690,550, a potent, orally active JAK inhibitor, in patients with active rheumatoid arthritis (RA) …

Objective To assess the efficacy and safety of rilonacept (Interleukin‐1 [IL‐1] Trap), a long‐
acting and potent inhibitor of IL‐1, in patients with cryopyrin‐associated periodic syndromes …

Objective Data regarding cardiovascular comorbidity and cardiovascular risk factors in
patients with psoriatic arthritis (PsA) are limited. To evaluate the cardiovascular risk profile, a …

In severe untreated rheumatoid arthritis (RA), reductions in high-density lipoprotein-
cholesterol, low-density lipoprotein-cholesterol and total cholesterol have been noted; this is …

Signaling pathways induced by the proinflammatory cytokine tumor necrosis factor alpha
(TNF-α) play a key role in the cellular responses to inflammation and injury. In the …

Psoriasis is a chronic and debilitating inflammatory disease associated with serious
comorbidities. Psoriasis can have a significant impact on a patient's quality of life and is …

Objective Rheumatoid arthritis is associated with increased cardiovascular risk. In
ankylosing spondylitis (AS), there is a paucity of information concerning this risk. Our …