Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
Rarely has a chemical elicited as much controversy as dichloroacetate (DCA). DCA was
initially considered a dangerous toxic industrial waste product, then a potential treatment for …
initially considered a dangerous toxic industrial waste product, then a potential treatment for …
Identification of a Novel Target Implicated in Chronic Obstructive Sleep Apnea-Related Atrial Fibrillation by Integrative Analysis of Transcriptome and Proteome
J Shen, J Liang, M Rejiepu, P Yuan… - Journal of …, 2023 - Taylor & Francis
Objective This study aimed to identify a newly identified target involved in atrial fibrillation
(AF) linked to chronic obstructive sleep apnea (COSA) through an integrative analysis of …
(AF) linked to chronic obstructive sleep apnea (COSA) through an integrative analysis of …
Age-related changes in expression and activity of human hepatic mitochondrial glutathione transferase Zeta1
Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent
dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in …
dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in …
Effects of multiple doses of dichloroacetate on GSTZ1 expression and activity in liver and extrahepatic tissues of young and adult rats
EJ Squirewell, MG Smeltz, L Rowland-Faux… - Drug Metabolism and …, 2020 - ASPET
Glutathione transferase zeta 1 (GSTZ1), expressed in liver and several extrahepatic tissues,
catalyzes dechlorination of dichloroacetate (DCA) to glyoxylate. DCA inactivates GSTZ1 …
catalyzes dechlorination of dichloroacetate (DCA) to glyoxylate. DCA inactivates GSTZ1 …
Mitochondrial glutathione transferase zeta 1 is inactivated more rapidly by dichloroacetate than the cytosolic enzyme in adult and juvenile rat liver
Dichloroacetate (DCA) has potential for treating mitochondrial disorders and cancer by
activating the mitochondrial pyruvate dehydrogenase complex. Repeated dosing of DCA …
activating the mitochondrial pyruvate dehydrogenase complex. Repeated dosing of DCA …
Pharmacokinetic and biochemical profiling of sodium dichloroacetate in pregnant ewes and fetuses
S Joseph, A Sharma, LP Horne, CE Wood… - Drug Metabolism and …, 2021 - ASPET
Sodium dichloroacetate (DCA) is an investigational drug that shows promise in the treatment
of acquired and congenital mitochondrial diseases, including myocardial ischemia and …
of acquired and congenital mitochondrial diseases, including myocardial ischemia and …
Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD (P) H Dehydrogenase [Quinone] 1
EJ Squirewell, R Mareus, LP Horne… - Drug Metabolism and …, 2020 - ASPET
Dichloroacetate (DCA) is an investigational drug that is used in the treatment of various
congenital and acquired disorders of energy metabolism. Although DCA is generally well …
congenital and acquired disorders of energy metabolism. Although DCA is generally well …