Background: Perturbations in coagulation function are common following trauma and are
associated with poor clinical outcomes. Traditionally considered an iatrogenic process, it is …

BACKGROUND Bleeding is the most frequent cause of preventable death after severe
injury. Our purposes were to study the efficacy of tranexamic acid (TXA) and prothrombin …

Objectives: Accidental hypothermia increases mortality and morbidity after hemorrhage, but
controversial data are available on the effects of therapeutic hypothermia. Therefore, we …

BACKGROUND Resuscitative endovascular balloon occlusion of the aorta (REBOA) has
emerged as an alternative to gauze packing (GP) in the setting of noncompressible torso …

Acute traumatic coagulopathy (ATC) is an acute and endogenous mechanism triggered by
the association of trauma and hemorrhage. Several animal models have been developed …

BACKGROUND Despite improvements in the management of severely injured patients,
development of multiple organ dysfunction syndrome (MODS) remains a morbid …

BACKGROUND Tranexamic acid (TXA) is an antifibrinolytic with anti-inflammatory
properties associated with improved outcomes when administered to trauma patients at risk …

Background Injury-related coagulopathy is a complex process. We analyzed coagulation in
a swine model of shock using rotational thromboelastometry (ROTEM). Methods Forty-eight …

Uncontrolled bleeding remains one of the leading causes of trauma-induced death.
Treatment recommendations focus on fresh frozen plasma and blood cell transfusions …

Background: Hemorrhagic shock and trauma are associated with acidosis and altered
coagulation. A fall in pH has been reported to attenuate the activity of recombinant activated …