Thrombosis and hemorrhage are major contributors to morbidity and mortality. The
traditional laboratory tests do not supply enough information to diagnose and treat patients …

Thrombin plays an essential role in achieving and maintaining effective hemostasis and
stable clot formation. In people with hemophilia, deficiency of procoagulant factor (F) VIII or …

Purpose To assess the epidemiology of intensive care unit (ICU) patients with
thrombocytopenia (TP). Methods All consecutive ICU-admitted patients with TP either on …

Aim We describe a 1-year experience with extracorporeal cardiopulmonary resuscitation
(ECPR) for in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA) associated with …

Abstract Introduction The ST Genesia is a benchtop, fully automated thrombin generation
(TG) device. It is completely standardized and ensures a uniform heat distribution throughout …

Background A sufficient plasma level of fibrinogen is critical for the formation of a fibrin clot
and haemostasis in both the perioperative setting and in massive haemorrhage. We …

Current mechanistic knowledge of protein interactions driving blood coagulation has come
largely from experiments with simple synthetic systems, which only partially represent the …

BACKGROUND: Rapid and accurate determination of prothrombin time in trauma patients
may help to faster control of bleeding induced coagulopathy. The goal of this prospective …

Background Few studies have characterised massive blood transfusion (MBT) practice in
UK trauma. This study describes the Trauma Audit and Research Network experience of …

Cardiac surgery with cardiopulmonary bypass (CPB) is associated with blood loss and post-
surgery thrombotic complications. The process of thrombin generation is disturbed during …