Basic biology of Trypanosoma cruzi

AA Zuma, E dos Santos Barrias… - Current pharmaceutical …, 2021 - ingentaconnect.com
The present review addresses basic aspects of the biology of the pathogenic protozoa
Trypanosoma cruzi and some comparative information of Trypanosoma brucei. Like …

Protozoan phagotrophy from predators to parasites: An overview of the enigmatic cytostome‐cytopharynx complex of Trypanosoma cruzi

RD Etheridge - Journal of Eukaryotic Microbiology, 2022 - Wiley Online Library
Eating is fundamental and from this basic principle, living organisms have evolved
innumerable strategies to capture energy and nutrients from their environment. As part of the …

Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies

EC Arrua, O Hartwig, B Loretz, X Murgia, DK Ho… - International Journal of …, 2023 - Elsevier
Benznidazole, a poorly soluble in water drug, is the first-line medication for the treatment of
Chagas disease, but long treatment periods at high dosages cause several adverse effects …

Trypanosoma cruzi heme responsive gene (TcHRG) plays a central role in orchestrating heme uptake in epimastigotes

E Tevere, CB Di Capua, NM Chasen… - The FEBS …, 2024 - Wiley Online Library
Trypanosoma cruzi, a heme auxotrophic parasite, can control intracellular heme content by
modulating heme responsive gene (Tc HRG) expression when a free heme source is added …

Phagocytosis underpins the biotrophic lifestyle of intracellular parasites in the class Phytomyxea (Rhizaria)

A Garvetto, P Murúa, M Kirchmair… - New …, 2023 - Wiley Online Library
Phytomyxea are intracellular biotrophic parasites infecting plants and stramenopiles,
including the agriculturally impactful Plasmodiophora brassicae and the brown seaweed …

The intracellular amastigote of Trypanosoma cruzi maintains an actively beating flagellum

MM Won, T Krüger, M Engstler, BA Burleigh - MBio, 2023 - Am Soc Microbiol
Throughout its complex life cycle, the uniflagellate parasitic protist, Trypanosoma cruzi,
adapts to different host environments by transitioning between elongated motile extracellular …

Dynamics of the orphan myosin MyoF over Trypanosoma cruzi life cycle and along the endocytic pathway

AA Alves, CL Alcantara, MVA Dantas-Jr… - Parasitology …, 2022 - Elsevier
Trypanosoma cruzi proliferative forms perform endocytosis through a specialized structure
named the cytostome-cytopharynx complex (SPC). The SPC is a specialized invagination of …

The cytostome‐cytopharynx complex of intracellular and extracellular amastigotes of Trypanosoma cruzi exhibit structural and functional differences

CL Alcantara, W de Souza… - Cellular …, 2021 - Wiley Online Library
Endocytosis in Trypanosoma cruzi is mainly performed through a specialised membrane
domain called cytostome‐cytopharynx complex. Its ultrastructure and dynamics in …

The functional characterization of TcMyoF implicates a family of cytostome-cytopharynx targeted myosins as integral to the endocytic machinery of Trypanosoma cruzi

NM Chasen, MG Etheridge, RD Etheridge - Msphere, 2020 - Am Soc Microbiol
Of the pathogenic trypanosomatids, Trypanosoma cruzi alone retains an ancient feeding
apparatus known as the cyto s tome-cyto p harynx c omplex (SPC) that it uses as its primary …

Life Cycle of Pathogenic Protists: Trypanosoma cruzi

E Barrias, A Zuma, W de Souza - Lifecycles of Pathogenic Protists in …, 2022 - Springer
Trypanosoma cruzi is the agent of Chagas disease with a high prevalence in Latin America.
This protozoan presents a complex life cycle in the invertebrate (hematophagous …