A structural view of miRNA biogenesis and function

AL Leitão, FJ Enguita - Non-coding RNA, 2022 - mdpi.com
Micro-RNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) that act as post-
transcriptional regulators of gene expression. Since their discovery in 1993, they have been …

Preliminary report on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Spike mutation T478K

S Di Giacomo, D Mercatelli… - Journal of medical …, 2021 - Wiley Online Library
Several severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants have
emerged, posing a renewed threat to coronavirus disease 2019 containment and to vaccine …

Soft computing techniques for biomedical data analysis: open issues and challenges

EH Houssein, ME Hosney, MM Emam… - Artificial Intelligence …, 2023 - Springer
In recent years, medical data analysis has become paramount in delivering accurate
diagnoses for various diseases. The plethora of medical data sources, encompassing …

A novel hybrid Harris hawks optimization and support vector machines for drug design and discovery

EH Houssein, ME Hosney, D Oliva… - Computers & Chemical …, 2020 - Elsevier
Cheminformatics has main research factors due to increasing size of the search space of
chemical compound databases and the importance of similarity measurements for drug …

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action

Y Yan, Q Liu, X Zang, S Yuan, U Bat-Erdene, C Nguyen… - Nature, 2018 - nature.com
Bioactive natural products have evolved to inhibit specific cellular targets and have served
as lead molecules for health and agricultural applications for the past century,–. The post …

ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species

H Yan, H Jiao, Q Liu, Z Zhang, Q Xiong… - Nature ecology & …, 2021 - nature.com
Bats are the suggested natural hosts for severe acute respiratory syndrome coronavirus
(SARS-CoV) and the causal agent of the coronavirus disease 2019 (COVID-19) pandemic …

Hybrid Harris hawks optimization with cuckoo search for drug design and discovery in chemoinformatics

EH Houssein, ME Hosney, M Elhoseny, D Oliva… - Scientific Reports, 2020 - nature.com
One of the major drawbacks of cheminformatics is a large amount of information present in
the datasets. In the majority of cases, this information contains redundant instances that …

Fuzzy-based hunger games search algorithm for global optimization and feature selection using medical data

EH Houssein, ME Hosney, WM Mohamed… - Neural Computing and …, 2023 - Springer
Feature selection (FS) is one of the basic data preprocessing steps in data mining and
machine learning. It is used to reduce feature size and increase model generalization. In …

A point mutation in the gene encoding magnesium chelatase I subunit influences strawberry leaf color and metabolism

YY Ma, JC Shi, DJ Wang, X Liang, F Wei… - Plant …, 2023 - academic.oup.com
Magnesium chelatase (MgCh) catalyzes the insertion of magnesium into protoporphyrin IX,
a vital step in chlorophyll (Chl) biogenesis. The enzyme consists of 3 subunits, MgCh I …

Enhanced Harris hawks optimization with genetic operators for selection chemical descriptors and compounds activities

EH Houssein, N Neggaz, ME Hosney… - Neural computing and …, 2021 - Springer
This paper presents modified versions of a recent swarm intelligence algorithm called Harris
hawks optimization (HHO) via incorporating genetic operators (crossover and mutation CM) …