Innovative anticancer therapies based on the activation of the immune system offer promise
in the battle against cancers resistant to traditional treatments. Examples of such therapeutic …

This Review aims to highlight key aspects of tetrapyrrole-based antibody–drug conjugates
(ADCs) and significant developments in the field since 2010. Many new conjugation …

Immune checkpoint blockade has recently proven effective in subsets of patients with
esophageal adenocarcinoma (EAC) but little is known regarding the EAC immune …

Photodynamic therapy (PDT) combines a photosensitizer (PS) with the physical energy of
non-ionizing light to trigger cell death pathways. PDT has potential as a therapeutic modality …

Soft tissue sarcoma (STS) is one of the most challenging tumors for medical oncologists,
with a high rate of recurrence after initial resection. In this study, a recurrent STS-specific …

Background Early detection of esophageal cancer is critical to improve survival. Whilst
studies have identified biomarkers, their interpretation and validity is often confounded by …

Background: Esophageal adenocarcinoma (EAC) is a growing problem with a rapidly rising
incidence and carries a poor prognosis. We aimed to develop a glycolysis-related gene …

Background The risk of esophageal adenocarcinoma (EAC) is associated with gastro‐
esophageal reflux disease (GERD) and obesity. Lipid metabolism‐targeted therapies …

Silencing of Chl1 gene expression has been previously reported to reduce insulin secretion.
Nevertheless, the mechanism underlying this effect remains unclear. In this study, we …

Antibodies targeting aberrantly glycosylated proteins are ineffective in treating cancer.
Antibody‐drug conjugates have emerged as effective alternatives, facilitating tumor‐specific …