Animal-to-human translation difficulties and problems with proposed coding-in-noise deficits in noise-induced synaptopathy and hidden hearing loss

S Ripley, L Xia, Z Zhang, SJ Aiken… - Frontiers in Neuroscience, 2022 - frontiersin.org
Noise induced synaptopathy (NIS) and hidden hearing loss (NIHHL) have been hot topic in
hearing research since a massive synaptic loss was identified in CBA mice after a brief …

Evaluation of hidden hearing loss in normal-hearing firearm users

SK Grinn, CG Le Prell - Frontiers in neuroscience, 2022 - frontiersin.org
Some noise exposures resulting in temporary threshold shift (TTS) result in cochlear
synaptopathy. The purpose of this retrospective study was to evaluate a human population …

Pre-exposure to lower-level noise mitigates cochlear synaptic loss induced by high-level noise

L Fan, Z Zhang, H Wang, C Li, Y Xing, S Yin… - Frontiers in systems …, 2020 - frontiersin.org
The auditory sensory organs appear to be less damaged by exposure to high-level noise
that is presented after exposure to non-traumatizing low-level noise. This phenomenon is …

Otoprotection to implanted cochlea exposed to noise trauma with dexamethasone eluting electrode

AA Eshraghi, A Wolfovitz, R Yilmazer… - Frontiers in cellular …, 2019 - frontiersin.org
Cochlear implantation (CI) is now widely used to provide auditory rehabilitation to
individuals having severe to profound sensorineural hearing loss (SNHL). However, CI can …

Hidden hearing loss: current perspectives and potential therapies

D Chen, G Jia, Y Ni, Y Chen - Journal of Bio-X Research, 2019 - spj.science.org
Hidden hearing loss (HHL), an auditory dysfunction that has gained much recent attention,
has the hallmarks of speech discrimination and intelligibility deficits with normal or near …

Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing

L Xia, S Ripley, Z Jiang, X Yin, Z Yu, SJ Aiken… - Frontiers in …, 2022 - frontiersin.org
Noise induced synaptopathy (NIS) has been researched extensively since a large amount of
synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief …

[HTML][HTML] Temporary versus permanent synaptic loss from repeated noise exposure in guinea pigs and C57 mice

Z Zhang, L Fan, Y Xing, J Wang, S Aiken, Z Chen… - Neuroscience, 2020 - Elsevier
A single brief noise exposure can cause a significant loss of cochlear afferent synapses
without causing permanent threshold shift. Previously we reported that the initial synaptic …

Middle Ear Muscle Reflex in Normal-Hearing Individuals with Occupational Noise Exposure

S Vasudevamurthy, AU Kumar - Noise and Health, 2023 - journals.lww.com
Objectives: Noise-induced cochlear synaptopathy is studied extensively in animal models.
The diagnosis of synaptopathy in humans is challenging and the roles of many noninvasive …

Transcriptomic analysis reveals an altered Hcy metabolism in the stria vascularis of the pendred syndrome mouse model

W Xue, Y Tian, Y Xiong, F Liu, Y Feng, Z Chen… - Neural …, 2021 - Wiley Online Library
Purpose. Slc26a4-/-mice exhibit severer defects in the development of the cochlea and
develop deafness, while the underlying mechanisms responsible for these effects remain …

Effect of Occupational Noise Exposure on Cognition and Suprathreshold Auditory Skills in Normal-Hearing Individuals

S Vasudevamurthy, A Kumar U - American Journal of Audiology, 2022 - ASHA
Objectives: Adverse effects of noise exposure on hearing and cognition are well
documented in the literature. Recently, it has becoming increasingly evident that noise …