Neonatal hypoglycemia and brain vulnerability

LC De Angelis, G Brigati, G Polleri, M Malova… - Frontiers in …, 2021 - frontiersin.org
Neonatal hypoglycemia is a common condition. A transient reduction in blood glucose
values is part of a transitional metabolic adaptation following birth, which resolves within the …

Neuronal damage and cognitive impairment associated with hypoglycemia: an integrated view

G Languren, T Montiel, A Julio-Amilpas… - Neurochemistry …, 2013 - Elsevier
The aim of the present review is to offer a current perspective about the consequences of
hypoglycemia and its impact on the diabetic disorder due to the increasing incidence of …

The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat

SE Kanoski, Y Zhang, W Zheng… - Journal of Alzheimer's …, 2010 - content.iospress.com
Cognitive impairment and Alzheimer's disease are linked with intake of a Western diet,
characterized by high levels of saturated fats and simple carbohydrates. In rats, these dietary …

Increased oxidative stress and imbalance in antioxidant enzymes in the brains of alloxan‐induced diabetic rats

LB Ceretta, GZ Réus, HM Abelaira… - Journal of Diabetes …, 2012 - Wiley Online Library
Diabetes Mellitus (DM) is associated with pathological changes in the central nervous
system (SNC) as well as alterations in oxidative stress. Thus, the main objective of this study …

Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen …

A Julio-Amilpas, T Montiel… - Journal of Cerebral …, 2015 - journals.sagepub.com
Glucose is the main energy substrate in brain but in certain circumstances such as
prolonged fasting and the suckling period alternative substrates can be used such as the …

A mitocentric view of Alzheimer's disease suggests multi-faceted treatments

GE Gibson, Q Shi - Journal of Alzheimer's disease, 2010 - content.iospress.com
Alzheimer's disease (AD) is defined by senile plaques made of amyloid-β peptide (Aβ),
neurofibrillary tangles made of hyperphosphorylated tau proteins, and memory deficits …

Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats

SJ Won, BH Yoo, TM Kauppinen, BY Choi… - Journal of …, 2012 - Springer
Abstract Background Recurrent/moderate (R/M) hypoglycemia is common in type 1
diabetes. Although mild or moderate hypoglycemia is not life-threatening, if recurrent, it may …

Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability

X Wang, ML Michaelis, EK Michaelis - Current genomics, 2010 - ingentaconnect.com
Pivotal brain functions, such as neurotransmission, cognition, and memory, decline with
advancing age and, especially, in neurodegenerative conditions associated with aging …

Experimental models of chemically induced Parkinson's disease in zebrafish at the embryonic larval stage: a systematic review

P Briñez-Gallego, DG da Costa Silva… - Journal of Toxicology …, 2023 - Taylor & Francis
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic neurons in the substantia nigra that results in a decrease in dopamine levels …

Neuroprotective effect of silibinin in diabetic mice

G Marrazzo, P Bosco, F La Delia, G Scapagnini… - Neuroscience …, 2011 - Elsevier
Diabetes mellitus is associated with a higher oxidative stress and reduced activity of the
antioxidant defense system in different brain regions. Results from numerous studies …