The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …

Acute myeloid leukemia (AML) is characterized by accumulation of myeloid cells in the bone
marrow because of impaired differentiation and proliferation, resulting in hematopoietic …

The dysregulation of developmental and stem cell–associated genes is a common
phenomenon during cancer development. Around half of patients with acute myeloid …

Periodontitis is an extremely prevalent disease worldwide and is driven by complex
dysbiotic microbiota. Here we analyzed the transcriptional activity of the periodontal pocket …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

Programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1)
interaction plays a crucial role in tumor-associated immune escape. Here, we verify that …

The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …

At a first glance, ribosome biogenesis and chromatin remodeling are quite different
processes, but they share a common problem involving interactions between charged …

Nucleophosmin (NPM, also known as B23, numatrin or NO38) is a ubiquitously expressed
phosphoprotein belonging to the nucleoplasmin family of chaperones. NPM is mainly …

The nucleolus is a compartmentalized organelle in eukaryotic cells known to form during
embryogenesis, yet how its layered architecture is transformed from homogenous precursor …