NPM1-mutated acute myeloid leukemia: from bench to bedside
The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
Biological and clinical consequences of NPM1 mutations in AML
Acute myeloid leukemia (AML) is characterized by accumulation of myeloid cells in the bone
marrow because of impaired differentiation and proliferation, resulting in hematopoietic …
marrow because of impaired differentiation and proliferation, resulting in hematopoietic …
Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia
HJ Uckelmann, EL Haarer, R Takeda, EM Wong… - Cancer discovery, 2023 - AACR
The dysregulation of developmental and stem cell–associated genes is a common
phenomenon during cancer development. Around half of patients with acute myeloid …
phenomenon during cancer development. Around half of patients with acute myeloid …
[HTML][HTML] Dysbiosis in chronic periodontitis: key microbial players and interactions with the human host
ZL Deng, SP Szafrański, M Jarek, S Bhuju… - Scientific reports, 2017 - nature.com
Periodontitis is an extremely prevalent disease worldwide and is driven by complex
dysbiotic microbiota. Here we analyzed the transcriptional activity of the periodontal pocket …
dysbiotic microbiota. Here we analyzed the transcriptional activity of the periodontal pocket …
[HTML][HTML] Sirtuins in epigenetic regulation
1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …
[HTML][HTML] NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer
G Qin, X Wang, S Ye, Y Li, M Chen, S Wang… - Nature …, 2020 - nature.com
Programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1)
interaction plays a crucial role in tumor-associated immune escape. Here, we verify that …
interaction plays a crucial role in tumor-associated immune escape. Here, we verify that …
Nucleolus: a central hub for nuclear functions
The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …
far from being comprehensively understood. Much work on the nucleolus has focused on its …
NPM1/B23: a multifunctional chaperone in ribosome biogenesis and chromatin remodeling
MS Lindström - Biochemistry research international, 2011 - Wiley Online Library
At a first glance, ribosome biogenesis and chromatin remodeling are quite different
processes, but they share a common problem involving interactions between charged …
processes, but they share a common problem involving interactions between charged …
Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases
E Colombo, M Alcalay, PG Pelicci - Oncogene, 2011 - nature.com
Nucleophosmin (NPM, also known as B23, numatrin or NO38) is a ubiquitously expressed
phosphoprotein belonging to the nucleoplasmin family of chaperones. NPM is mainly …
phosphoprotein belonging to the nucleoplasmin family of chaperones. NPM is mainly …
Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment
The nucleolus is a compartmentalized organelle in eukaryotic cells known to form during
embryogenesis, yet how its layered architecture is transformed from homogenous precursor …
embryogenesis, yet how its layered architecture is transformed from homogenous precursor …