Salmonella bacteria cause millions of infections and thousands of deaths every year. This
pathogen has an unusually broad host range including humans, animals, and even plants …

The ability of intracellular pathogens to subvert the host response, to facilitate invasion and
subsequent infection, is the hallmark of microbial pathogenesis. Bacterial pathogens …

During infection, Salmonella species inject multiple type III secretion system (T3SS) effector
proteins into host cells that mediate invasion and subsequent intracellular replication. At …

Salmonella Typhimurium is an intracellular pathogen that causes gastroenteritis in humans.
Aided by a battery of effector proteins, S. Typhimurium resides intracellularly in a specialized …

Background Tumor necrosis factor alpha (TNF-α) plays a central role in the initiation and
maintenance of immune responses to periodontopathic bacteria. However, excess TNF-α …

SipA is a major effector of Salmonella, which causes gastroenteritis and enteric fever.
Caspase-3 cleaves SipA into two domains: the C-terminal domain regulates actin …

The cell is compartmentalised into complex micro-environments allowing an array of
specialised biological processes to be carried out in synchrony. Determining a protein's sub …

Processes such as cell migration, phagocytosis, endocytosis, and exocytosis refer to the
intense exchange of information between the internal and external environment in the cells …

We identified a glucosyltransferase (YGT) and an ADP-ribosyltransferase (YART) in Yersinia
mollaretii, highly related to glucosylating toxins from Clostridium difficile, the cause of …

Pseudomonas aeruginosa, a Gram-negative opportunistic human pathogen, is a frequent
cause of severe hospital-acquired infections. Effectors produced by the type III secretion …