Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved
physicochemical properties, which has attracted increased interests from both industrial and …

Cocrystals can be used as an alternative approach based on crystal engineering to enhance
specific physicochemical and biopharmaceutical properties of active pharmaceutical …

Over the last 20 years, the number of publications outlining the advances in design
strategies, growing techniques, and characterization of cocrystals has continued to increase …

Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient
are the major constraints during the development of new product. Various approaches have …

This review article focuses on the interaction among certain scientific, legal, and regulatory
aspects of pharmaceutical crystal forms. The article offers an analysis of pharmaceutical …

The pre-formulation of pharmaceutical cocrystals and salts is a concept of crystal
engineering that has emerged as a promising technique for drug development in …

Since the introduction of aspirin in 1899, and more par-ticularly since the advent of antibiotic
''wonder drugs''in the 1940s, society has come to rely on the widespread availability of …