[HTML][HTML] Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication
Current medical countermeasures for organophosphate (OP)-induced status epilepticus
(SE) are not effective in preventing long-term morbidity and there is an urgent need for …
(SE) are not effective in preventing long-term morbidity and there is an urgent need for …
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies
Unhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition,
gradually increasing the risk for mild cognitive impairment (MCI) and the continuum …
gradually increasing the risk for mild cognitive impairment (MCI) and the continuum …
[HTML][HTML] Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness
KF Phillips, LS Deshpande - Neurotoxicology, 2016 - Elsevier
Abstract Approximately 175,000–250,000 of the returning veterans from the 1991 Persian
Gulf War exhibit chronic multi-symptom illnesses that includes neurologic co-morbidities …
Gulf War exhibit chronic multi-symptom illnesses that includes neurologic co-morbidities …
Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy
V Aroniadou-Anderjaska, TH Figueiredo… - Neurobiology of …, 2020 - Elsevier
One of the devastating effects of acute exposure to organophosphates, like nerve agents, is
the induction of severe and prolonged status epilepticus (SE), which can cause death, or …
the induction of severe and prolonged status epilepticus (SE), which can cause death, or …
Neuroinflammation as a therapeutic target for mitigating the long-term consequences of acute organophosphate intoxication
Acute intoxication with organophosphates (OPs) can cause a potentially fatal cholinergic
crisis characterized by peripheral parasympathomimetic symptoms and seizures that rapidly …
crisis characterized by peripheral parasympathomimetic symptoms and seizures that rapidly …
Ratiometric detection of nerve agents by coupling complementary properties of silicon-based quantum dots and green fluorescent protein
CJT Robidillo, S Wandelt, R Dalangin… - … applied materials & …, 2019 - ACS Publications
Ratiometric photoluminescent detection of the toxicologically potent organophosphate ester
nerve agents paraoxon (PX) and parathion (PT) using the complementary optical and …
nerve agents paraoxon (PX) and parathion (PT) using the complementary optical and …
Neuroinflammation in organophosphate-induced neurotoxicity
Organophosphates (OPs) are a group of synthetic compounds that are neurotoxic in humans
and preclinical models. The canonical mechanism of OP neurotoxicity is inhibition of …
and preclinical models. The canonical mechanism of OP neurotoxicity is inhibition of …
Brain-targeted nanoreactors prevent the development of organophosphate-induced delayed neurological damage
S Zou, Q Wang, Q He, G Liu, J Song, J Li… - Journal of …, 2023 - Springer
Background Organophosphate (OP)-induced delayed neurological damage is attributed to
permanent neuropathological lesions caused by irreversible OP-neurocyte interactions …
permanent neuropathological lesions caused by irreversible OP-neurocyte interactions …
Repeated exposure to chlorpyrifos is associated with a dose-dependent chronic neurobehavioral deficit in adult rats
ACR Ribeiro, E Hawkins, FM Jahr, JL McClay… - Neurotoxicology, 2022 - Elsevier
Organophosphate (OP) chemicals include commonly used pesticides and chemical warfare
agents, and mechanistically they are potent inhibitors of the cholinesterase (ChE) enzyme …
agents, and mechanistically they are potent inhibitors of the cholinesterase (ChE) enzyme …
Repurposing cholinesterase inhibitors as antidepressants? Dose and stress-sensitivity may be critical to opening possibilities
When stress becomes chronic it can trigger lasting brain and behavioral changes including
Major Depressive Disorder (MDD). There is conflicting evidence regarding whether …
Major Depressive Disorder (MDD). There is conflicting evidence regarding whether …