Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections

U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Exploring antibiotic resistance with chemical tools

WA Velema - Chemical Communications, 2023 - pubs.rsc.org
Antibiotic resistance is an enormous problem that is accountable for over a million deaths
annually, with numbers expected to significantly increase over the coming decades …

[HTML][HTML] Chatting with artificial intelligence to combat antibiotic resistance: Opportunities and challenges

M Abavisani, A Khoshrou, SK Foroushan… - Current Research in …, 2024 - Elsevier
Antibiotic resistance (ABR) is a dire global health crisis, undermining the efficacy of
antibiotics and ranking among the top ten public health threats according to the World …

Phase‐Separated Nano‐Antibiotics Enhanced Survival in Multidrug‐Resistant Escherichia coli Sepsis by Precise Periplasmic EcDsbA Targeting

P Zou, L Huang, Y Li, D Liu, J Che, T Zhao… - Advanced …, 2024 - Wiley Online Library
Disulfide bond (Dsb) proteins, especially DsbA, represent a promising but as‐yet‐unrealized
target in combating multidrug‐resistant (MDR) bacteria because their precise subcellular …

Multifunctional chitosan-cross linked-curcumin-tannic acid biocomposites disrupt quorum sensing and biofilm formation in pathogenic bacteria

ZA Khan, MY Wani, A Ahmad, MT Basha, NA Aly… - International Journal of …, 2024 - Elsevier
Natural products have a long history of success in treating bacterial infections, making them
a promising source for novel antibacterial medications. Curcumin, an essential component …

Isolation, whole-genome sequencing, and annotation of two antibiotic-producing and antibiotic-resistant bacteria, Pantoea rodasii RIT 836 and Pseudomonas …

S Tuytschaevers, L Aden, Z Greene, C Nixon, W Shaw… - Plos one, 2024 - journals.plos.org
Antimicrobial resistance (AMR) is a global threat to human health since infections caused by
antimicrobial-resistant bacteria are life-threatening conditions with minimal treatment …

Heterocyclic Diaryliodonium-Based Inhibitors of Carbapenem-Resistant Acinetobacter baumannii

P Kumari, G Kaul, TA Kumar, A Akhir… - Microbiology …, 2023 - Am Soc Microbiol
Finding new therapeutic strategies against Gram-negative pathogens such as Acinetobacter
baumannii is challenging. Starting from diphenyleneiodonium (dPI) salts, which are …

[PDF][PDF] Exploration de l'incorporation métabolique de précurseurs d'acides téichoïques et du peptidoglycane chez Streptococcus pneumoniae

M Baudoin - 2023 - theses.fr
Despite the antibiotics currently on the market, we observe, these past years, an increase of
deaths due to bacterial infections. The main cause of this increase is the development of …