The human virome: assembly, composition and host interactions

G Liang, FD Bushman - Nature Reviews Microbiology, 2021 - nature.com
The human body hosts vast microbial communities, termed the microbiome. Less well
known is the fact that the human body also hosts vast numbers of different viruses …

The gut virome: A new microbiome component in health and disease

Z Cao, N Sugimura, E Burgermeister, MP Ebert… - …, 2022 - thelancet.com
The human gastrointestinal tract harbours an abundance of viruses, collectively known as
the gut virome. The gut virome is highly heterogeneous across populations and is linked to …

Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

MP Nekoua, EK Alidjinou, D Hober - Nature Reviews Endocrinology, 2022 - nature.com
Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Expanding known viral diversity in the healthy infant gut

SA Shah, L Deng, J Thorsen, AG Pedersen… - Nature …, 2023 - nature.com
The gut microbiome is shaped through infancy and impacts the maturation of the immune
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …

Microbial genes and pathways in inflammatory bowel disease

M Schirmer, A Garner, H Vlamakis… - Nature Reviews …, 2019 - nature.com
Perturbations in the intestinal microbiome are implicated in inflammatory bowel disease
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …

A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases

MJ Tisza, CB Buck - … of the National Academy of Sciences, 2021 - National Acad Sciences
Despite remarkable strides in microbiome research, the viral component of the microbiome
has generally presented a more challenging target than the bacteriome. This gap persists …

The infant gut virome is associated with preschool asthma risk independently of bacteria

C Leal Rodríguez, SA Shah, MA Rasmussen… - Nature Medicine, 2024 - nature.com
Bacteriophage (also known as phage) communities that inhabit the gut have a major effect
on the structure and functioning of bacterial populations, but their roles and association with …

[HTML][HTML] The gut virome database reveals age-dependent patterns of virome diversity in the human gut

AC Gregory, O Zablocki, AA Zayed, A Howell… - Cell host & …, 2020 - cell.com
The gut microbiome profoundly affects human health and disease, and their infecting viruses
are likely as important, but often missed because of reference database limitations. Here, we …

Type 1 diabetes—early life origins and changing epidemiology

JM Norris, RK Johnson, LC Stene - The lancet Diabetes & …, 2020 - thelancet.com
Type 1 diabetes is a chronic, immune-mediated disease characterised by the destruction of
insulin-producing cells. Standardised registry data show that type 1 diabetes incidence has …

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

T Yang, EM Richards, CJ Pepine… - Nature Reviews …, 2018 - nature.com
Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …