The signal recognition particle (SRP) and its receptor compose a universally conserved and
essential cellular machinery that couples the synthesis of nascent proteins to their proper …

The early events in the life of newly synthesized proteins in the cellular environment are
remarkably complex. Concurrently with their synthesis by the ribosome, nascent …

Summary The yeast Hsp70 chaperone Ssb interacts with ribosomes and nascent
polypeptides to assist protein folding. To reveal its working principle, we determined the …

Shwachman-Diamond syndrome (SDS)(OMIM# 260400) is a rare inherited bone marrow
failure syndrome (IBMFS) that is primarily characterized by neutropenia and exocrine …

Protein translocation into the endoplasmic reticulum (ER) is the first and decisive step in the
biogenesis of most extracellular and many soluble organelle proteins in eukaryotic cells. It is …

Cotranslational translocation of proteins across or into membranes is a vital process in all
kingdoms of life. It requires that the translating ribosome be targeted to the membrane by the …

Co-translational protein targeting to the endoplasmic reticulum (ER), represents an
evolutionary-conserved mechanism to target proteins into the secretory pathway. In this …

During ribosome-associated quality control, stalled ribosomes are split into subunits and the
60S-housed nascent polypeptides are poly-ubiquitinated by Listerin. How this low …

During protein biosynthesis, nascent polypeptide chains that emerge from the ribosomal exit
tunnel encounter ribosome-associated chaperones, which assist their folding to the native …

Despite the rising knowledge about ribosome function and structure and how ribosomal
subunits assemble in vitro in bacteria, the in vivo role of many ribosomal proteins remains …