The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

Efforts to identify the genetic underpinnings of rare undiagnosed diseases increasingly
involve the use of next-generation sequencing and comparative genomic hybridization …

Cellular viability requires tight regulation of actin cytoskeletal dynamics. Distinct families of
nucleation-promoting factors enable the rapid assembly of filament nuclei that elongate and …

Autosomal recessive (AR) gene defects are the leading genetic cause of intellectual
disability (ID) in countries with frequent parental consanguinity, which account for about …

Approximately 1% of the global population is affected by intellectual disability (ID), and the
majority receive no molecular diagnosis. Previous studies have indicated high levels of …

The small size of dendritic spines belies the elaborate role they play in excitatory synaptic
transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is …

Lead (Pb) exposure causes immeasurable damage to multiple human systems, particularly
the central nervous system (CNS). In this study, human induced pluripotent stem cells …

Circular RNA s (circ RNA s) have been recently identified as a naturally occurring family of
widespread and diverse endogenous non‐coding RNA s that may regulate gene expression …

Purpose This study aimed to undertake a multidisciplinary characterization of the phenotype
associated with SOX11 variants. Methods Individuals with protein altering variants in SOX11 …

Oligomeric Amyloid β1–42 (Aβ) plays a crucial synaptotoxic role in Alzheimer's disease, and
hyperphosphorylated tau facilitates Aβ toxicity. The link between Aβ and tau, however …