A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Reproduction is required for the survival of all mammalian species, and thousands of
essential'sex'genes are conserved through evolution. Basic research helps to define these …

Cell fate decisions require appropriate regulation of key genes. Sox9, a direct target of SRY,
is pivotal in mammalian sex determination. In vivo high-throughput chromatin accessibility …

The mammalian Y chromosome acts as a dominant male determinant as a result of the
action of a single gene, Sry, whose role in sex determination is to initiate testis rather than …

SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex
determination. Recent studies in mice reveal that the major role of SRY is to achieve …

Arguably the most defining moment in our lives is fertilization, the point at which we inherit
either an X or a Y chromosome from our father. The profoundly different journeys of male …

Sex determination is a unique process that allows the study of multipotent progenitors and
their acquisition of sex-specific fates during differentiation of the gonad into a testis or an …

The genes encoding members of the wingless-related MMTV integration site (WNT) and
fibroblast growth factor (FGF) families coordinate growth, morphogenesis, and differentiation …