A polystyrene-supported 1, 5, 7-triazabicyclodec-5-ene (TBD) was used as a highly
recyclable and stable catalyst for the conversion of epoxy amines into various 2-oxazolidone …

The experimental approach taken and challenges overcome in developing a high-purity
production (> 100 g) scale process for the telescoped synthesis of the antibiotic ciprofloxacin …

In this article, we describe the process development efforts to improve the final methylation
step in the AMG 397 drug substance process, culminating in the execution of a Good …

A workflow for the development of organometallic processes in flow was applied to
synthesize 1-(5-bromopyridin-2-yl)-2-methylpropan-2-ol, a pharmaceutical intermediate. Key …

Abstract Mesoporous Mn‐Se/Al2O3 could be easily fabricated by calcining the selenium
sources with the manganese and aluminum hydroxides. It was an efficient catalyst for …

Over the last two decades, with the advent of continuous flow technologies, continuous
processes have emerged as a major area in organic synthesis. In this context, continuous …

We have successfully adapted a Suzuki–Miyaura coupling reaction to a continuous flow
process. The reaction was a triphasic mixture involved with two liquid phases that are only …

Corning developed AFR technology to support the synthetic industry as an ongoing effort
toward process intensification. 1 For this, switching the synthetic paradigm2 from traditional …