The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining
the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses …

Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and
mutations. Their clinical symptoms are different. However, individuals with NDDs have …

Recent advances in single-cell sequencing technologies have enabled simultaneous
measurement of multiple cellular modalities, but the combined detection of histone post …

Compacted heterochromatin blocks are prevalent in differentiated cells and present a barrier
to cellular reprogramming. It remains obscure how heterochromatin remodeling is …

Transposable elements (TEs) play a significant role in evolution, contributing to genetic
variation. However, TE mobilization in somatic cells is not well understood. Here, we …

During development eukaryotic gene expression is coordinated by dynamic changes in
chromatin structure. Measurements of accessible chromatin are used extensively to identify …

Metabolites are active controllers of cellular physiology, but their role in complex behaviors
is less clear. Here we report metabolic changes that occur during the transition between …

Highlights•A neuronal type is a testable hypothesis: similarity indicates functional
equivalency.•Image registration together with morphology algorithms defines types across …

Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin
relaxation and consequent unscheduled mobilization of transposable elements (TEs) are …

The precise control of gene expression by transcription factor networks is crucial to
organismal development. The predominant approach for mapping transcription factor …