[HTML][HTML] Cathepsin S (CTSS) activity in health and disease-A treasure trove of untapped clinical potential

P Smyth, J Sasiwachirangkul, R Williams… - Molecular aspects of …, 2022 - Elsevier
Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Cathepsin S: therapeutic, diagnostic, and prognostic potential

RDA Wilkinson, R Williams, CJ Scott… - Biological chemistry, 2015 - degruyter.com
Cathepsin S is a member of the cysteine cathepsin protease family. It is a lysosomal
protease which can promote degradation of damaged or unwanted proteins in the endo …

Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics

R Brown, S Nath, A Lora, G Samaha, Z Elgamal… - Respiratory …, 2020 - Springer
Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …

[HTML][HTML] Proteases in cardiometabolic diseases: Pathophysiology, molecular mechanisms and clinical applications

Y Hua, S Nair - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Cardiovascular disease is the leading cause of death in the US and other developed
countries. Metabolic syndrome, including obesity, diabetes/insulin resistance, hypertension …

The multifaceted role of the lysosomal protease cathepsins in kidney disease

P Cocchiaro, V De Pasquale, R Della Morte… - Frontiers in Cell and …, 2017 - frontiersin.org
Kidney disease is worldwide the 12th leading cause of death affecting 8–16% of the entire
population. Kidney disease encompasses acute (short-lasting episode) and chronic …

Purslane (Portulaca oleracea) seed consumption and aerobic training improves biomarkers associated with atherosclerosis in women with type 2 diabetes (T2D)

F Dehghan, R Soori, K Gholami, M Abolmaesoomi… - Scientific reports, 2016 - nature.com
The aim of this study was to investigate the responses of atherosclerosis plaque biomarkers
to purslane seed consumption and aerobic training in women with T2D. 196 women with …

Relationship between lysosomal dyshomeostasis and progression of diabetic kidney disease

M Wu, M Zhang, Y Zhang, Z Li, X Li, Z Liu, H Liu… - Cell Death & …, 2021 - nature.com
Lysosomes are organelles involved in cell metabolism, waste degradation, and cellular
material circulation. They play a key role in the maintenance of cellular physiological …

Cathepsin S cleavage of protease-activated receptor-2 on endothelial cells promotes microvascular diabetes complications

SK Vr, MN Darisipudi, S Steiger… - Journal of the …, 2016 - journals.lww.com
Endothelial dysfunction is a central pathomechanism in diabetes-associated complications.
We hypothesized a pathogenic role in this dysfunction of cathepsin S (Cat-S), a cysteine …

Cathepsin S as an inhibitor of cardiovascular inflammation and calcification in chronic kidney disease

BF Sena, JL Figueiredo, E Aikawa - Frontiers in Cardiovascular …, 2018 - frontiersin.org
Cardiovascular disease (CVD) is responsible for the majority of deaths in the developed
world. Particularly, in patients with chronic kidney disease (CKD), the imbalance of calcium …

[HTML][HTML] Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer

WL Liu, D Liu, K Cheng, YJ Liu, S Xing, P Chi, XH Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
To evaluate whether serum Cathepsin S (Cat S) could serve as a biomarker for the
diagnosis and prognosis of gastric cancer (GC), Enzyme-linked immuno sorbent assay …