[HTML][HTML] Cathepsin S (CTSS) activity in health and disease-A treasure trove of untapped clinical potential
P Smyth, J Sasiwachirangkul, R Williams… - Molecular aspects of …, 2022 - Elsevier
Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …
particular interest due to distinctive properties including a normal restricted expression …
Cathepsin S: therapeutic, diagnostic, and prognostic potential
RDA Wilkinson, R Williams, CJ Scott… - Biological chemistry, 2015 - degruyter.com
Cathepsin S is a member of the cysteine cathepsin protease family. It is a lysosomal
protease which can promote degradation of damaged or unwanted proteins in the endo …
protease which can promote degradation of damaged or unwanted proteins in the endo …
Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics
Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …
[HTML][HTML] Proteases in cardiometabolic diseases: Pathophysiology, molecular mechanisms and clinical applications
Y Hua, S Nair - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Cardiovascular disease is the leading cause of death in the US and other developed
countries. Metabolic syndrome, including obesity, diabetes/insulin resistance, hypertension …
countries. Metabolic syndrome, including obesity, diabetes/insulin resistance, hypertension …
The multifaceted role of the lysosomal protease cathepsins in kidney disease
P Cocchiaro, V De Pasquale, R Della Morte… - Frontiers in Cell and …, 2017 - frontiersin.org
Kidney disease is worldwide the 12th leading cause of death affecting 8–16% of the entire
population. Kidney disease encompasses acute (short-lasting episode) and chronic …
population. Kidney disease encompasses acute (short-lasting episode) and chronic …
Purslane (Portulaca oleracea) seed consumption and aerobic training improves biomarkers associated with atherosclerosis in women with type 2 diabetes (T2D)
The aim of this study was to investigate the responses of atherosclerosis plaque biomarkers
to purslane seed consumption and aerobic training in women with T2D. 196 women with …
to purslane seed consumption and aerobic training in women with T2D. 196 women with …
Relationship between lysosomal dyshomeostasis and progression of diabetic kidney disease
M Wu, M Zhang, Y Zhang, Z Li, X Li, Z Liu, H Liu… - Cell Death & …, 2021 - nature.com
Lysosomes are organelles involved in cell metabolism, waste degradation, and cellular
material circulation. They play a key role in the maintenance of cellular physiological …
material circulation. They play a key role in the maintenance of cellular physiological …
Cathepsin S cleavage of protease-activated receptor-2 on endothelial cells promotes microvascular diabetes complications
SK Vr, MN Darisipudi, S Steiger… - Journal of the …, 2016 - journals.lww.com
Endothelial dysfunction is a central pathomechanism in diabetes-associated complications.
We hypothesized a pathogenic role in this dysfunction of cathepsin S (Cat-S), a cysteine …
We hypothesized a pathogenic role in this dysfunction of cathepsin S (Cat-S), a cysteine …
Cathepsin S as an inhibitor of cardiovascular inflammation and calcification in chronic kidney disease
Cardiovascular disease (CVD) is responsible for the majority of deaths in the developed
world. Particularly, in patients with chronic kidney disease (CKD), the imbalance of calcium …
world. Particularly, in patients with chronic kidney disease (CKD), the imbalance of calcium …
[HTML][HTML] Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer
WL Liu, D Liu, K Cheng, YJ Liu, S Xing, P Chi, XH Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
To evaluate whether serum Cathepsin S (Cat S) could serve as a biomarker for the
diagnosis and prognosis of gastric cancer (GC), Enzyme-linked immuno sorbent assay …
diagnosis and prognosis of gastric cancer (GC), Enzyme-linked immuno sorbent assay …