The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided
biologists with a set of interacting proteins with diverse roles in organization and survival of …

All modern cells are bounded by cell membranes best described by the fluid mosaic model.
This statement is so widely accepted by biologists that little attention is generally given to the …

The inhibitory protein, IκBα, sequesters the transcription factor, NF-κB, as an inactive
complex in the cytoplasm. The structure of the IκBα ankyrin repeat domain, bound to a …

A novel Mr 28,000 integral membrane protein (" 28kDa") was identified in human
erythrocytes and found entirely associated with the Triton X-100 insoluble membrane …

The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex,
but how it tethers the spectrin–actin cytoskeleton to the lipid bilayer and the nature of its …

Exported proteins of the malaria parasite Plasmodium falciparum interact with proteins of the
erythrocyte membrane and induce substantial changes in the morphology, physiology and …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Adducin is a ubiquitously expressed membrane-skeletal protein localized at spectrin-actin
junctions that binds calmodulin and is an in vivo substrate for protein kinase C (PKC) and …

Ankyrin is a cytoskeletal adaptor protein that controls important cellular functions, including
Ca2+ efflux at inositol 1, 4, 5-trisphosphate receptors (IP3R) on the endoplasmic reticulum …

Human T-cell leukemia virus type III (HTLV-III) was recently identified as the probable
etiologic agent of the acquired immune deficiency syndrome (AIDS). Here it is shown that, in …