Role of substance P neuropeptide in inflammation, wound healing, and tissue homeostasis

S Suvas - The Journal of Immunology, 2017 - journals.aai.org
Substance P (SP) is an undecapeptide present in the CNS and the peripheral nervous
system. SP released from the peripheral nerves exerts its biological and immunological …

[HTML][HTML] Mechanistic investigations of diabetic ocular surface diseases

Q Zhou, L Yang, Q Wang, Y Li, C Wei… - Frontiers in …, 2022 - frontiersin.org
With the global prevalence of diabetes mellitus over recent decades, more patients suffered
from various diabetic complications, including diabetic ocular surface diseases that may …

Understanding the pathogenesis of neurotrophic keratitis: the role of corneal nerves

L Mastropasqua, G Massaro‐Giordano… - Journal of cellular …, 2017 - Wiley Online Library
Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by
trigeminal nerve damage, which leads to loss of corneal sensitivity, corneal epithelium …

[HTML][HTML] HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts

C Trapella, R Rizzo, S Gallo, A Alogna, D Bortolotti… - Scientific reports, 2018 - nature.com
Snail mucus is a mixture of active substances commonly thought to have healthy properties
for the treatment of skin disorders. Although snail mucus is an ingredient of several cosmetic …

Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders

RB Singh, A Naderi, W Cho, G Ortiz, A Musayeva… - The ocular …, 2022 - Elsevier
Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune
systems. SP is predominantly released by neurons and exerts its biological and …

The two-faced effects of nerves and neuropeptides in corneal diseases

RML Vitar, P Rama, G Ferrari - Progress in Retinal and Eye Research, 2022 - Elsevier
Corneal nerves are instrumental to maintain cornea integrity through regulation of key
physiological functions such as tear secretion, blink reflex, and neuropeptide turnover …

[HTML][HTML] Pathogenesis of herpes stromal keratitis: immune inflammatory response mediated by inflammatory regulators

L Wang, R Wang, C Xu, H Zhou - Frontiers in Immunology, 2020 - frontiersin.org
Herpes stromal keratitis (HSK) is one of the primary diseases that cause vision loss or even
blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is …

Autoimmunity in dry eye disease–an updated review of evidence on effector and memory Th17 cells in disease pathogenicity

Y Chen, R Dana - Autoimmunity reviews, 2021 - Elsevier
Abstract The classic Th1/Th2 dogma has been significantly reshaped since the subsequent
introduction of several new T helper cell subsets, among which the most intensively …

Keratocyte biology

GHF Yam, AK Riau, ML Funderburgh, JS Mehta… - Experimental eye …, 2020 - Elsevier
The study of corneal stromal keratocytes is motivated by its strong association with corneal
health and visual function. They play a dominant role in the maintenance of corneal …

The molecular basis of neurotrophic keratopathy: Diagnostic and therapeutic implications. A review

RE Ruiz-Lozano, JC Hernandez-Camarena… - The ocular …, 2021 - Elsevier
Neurotrophic keratopathy (NK) is a degenerative corneal disease produced by different
factors, including infection, trauma, and neurogenesis, that lead to trigeminal nerve damage …