There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

THE aorta at the thoracic or abdominal levels is cross-clamped during surgical procedures
for trauma and sometimes for resuscitation; more often, however, it is cross-clamped for …

Germline mutations in cellular-energy associated genes have been shown to lead to various
monogenic disorders. Notably, mitochondrial disorders often impact skeletal muscle, brain …

Concentrations of up to 1.5 milliunits/ml xanthine oxidase (XO)(1.1 μg/ml) are found
circulating in plasma during diverse inflammatory events. The saturable, high affinity binding …

Recent evidence in vivo indicates that spontaneously hypertensive rats (SHR) exhibit an
increase in oxyradical production in and around microvascular endothelium. This study is …

Ischaemia‐reperfusion injury (IRI) is of obvious relevance in situations where there is an
interruption of blood supply to the gut, as in vascular surgery, or in the construction of free …

evidence shows that they play necessary roles in normal signal transduction. 1 In low
concentrations, they are implicated as second messengers primarily through inhibition of …

During open aortic surgery, interrupting the blood flow through the aorta by applying a cross-
clamp is often a key step to allow for surgical repair. As a consequence, ischemia is induced …

Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular
disease. However, studies have frequently failed to distinguish whether these entities have …