There is considerable interest in the development of an inhibitor of aldo–keto reductase
(AKR) 1C3 (type 5 17β-hydroxysteroid dehydrogenase and prostaglandin F synthase) as a …

Human aldo-keto reductase family 1 member C3 (AKR1C3) is known as a hormone activity
regulator and prostaglandin F (PGF) synthase that regulates the occupancy of hormone …

Aldo–keto reductase (AKR) 1C3 catalyzes the synthesis of active androgens that promote
the progression of prostate cancer. AKR1C3 also contributes to androgen-independent cell …

The enzymes and pathways of steroidogenesis are central to an understanding of
adrenarche. The quantitative regulation of steroidogenesis occurs at the first step, the …

Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary …

Aldo-keto reductase (AKR) 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F
synthase) regulates ligand access to steroid hormone and prostaglandin receptors and may …

Background: The spirocyclic compounds have always aroused a great interest because this
motif is present as structural core in a number of natural products and bioactive compounds …

Oestradiol is a well-characterized sex hormone that stimulates breast cancer and other
oestrogen-related diseases. 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) …

In this study, we present the synthesis, kinetic studies of inhibitory activity toward aldo-keto
reductase 1C (AKR1C) enzymes, and anticancer potential toward chemoresistant ovarian …

Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl
groups in a number of important steroid and prostanoid molecules. The enzyme is also over …